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ID: ALA1138959
Journal: Bioorg Med Chem Lett
Title: Novel class of cyclophosphamide prodrug: cyclophosphamide spiropiperaziniums (CPSP).
Authors: Sun Q, Li RT, Guo W, Cui JR, Cheng TM, Ge ZM.
Abstract: A novel class of cyclophosphamide spiropiperaziniums was synthesized and evaluated for their in vivo anti-cancer activities against S180 and H22. Most of them exhibited definite activities. Especially, compounds 8b and 8k showed good anti-cancer activities, meanwhile, 8k also showed much lower toxicity than CP. Several interesting structure-activity relationships were revealed.
CiteXplore: 16682187