Discovery of potent CRTh2 (DP2) receptor antagonists.

ID: ALA1138972

Journal: Bioorg Med Chem Lett

Title: Discovery of potent CRTh2 (DP2) receptor antagonists.

Authors: Birkinshaw TN, Teague SJ, Beech C, Bonnert RV, Hill S, Patel A, Reakes S, Sanganee H, Dougall IG, Phillips TT, Salter S, Schmidt J, Arrowsmith EC, Carrillo JJ, Bell FM, Paine SW, Weaver R.

Abstract: Starting with the weak agonist indomethacin, a series of potent, selective CRTh2 (DP(2)) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases.

CiteXplore: 16753296

DOI: 10.1016/j.bmcl.2006.05.062

Patent ID: ┄