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ID: ALA1138977
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase.
Authors: Nencka R, Votruba I, Hrebabecký H, Tloust'ová E, Horská K, Masojídková M, Holý A.
Abstract: We report on a series of novel 5,6-disubstituted uracils with significant inhibitory activity against human and Escherichia coli thymidine phosphorylases. Bis-uracil conjugates were identified as the most potent inhibitors of TPs in this study.
CiteXplore: 16337119
DOI: 10.1016/j.bmcl.2005.11.050
Patent ID: ┄