Document Report Card

Basic Information

ID: ALA1138995

Journal: Bioorg Med Chem Lett

Title: Triaminotriazine DNA helicase inhibitors with antibacterial activity.

Authors: McKay GA, Reddy R, Arhin F, Belley A, Lehoux D, Moeck G, Sarmiento I, Parr TR, Gros P, Pelletier J, Far AR.

Abstract: Screening of a chemical library in a DNA helicase assay involving the Pseudomonas aeruginosa DnaB helicase provided a triaminotriazine inhibitor with good antibacterial activity but associated cytotoxicity toward mammalian cells. Synthesis of analogs provided a few inhibitors that retained antibacterial activity and demonstrated a significant reduction in cytotoxicity. The impact of serum and initial investigations toward a mode of action highlight several features of this class of compounds as antibacterials.

CiteXplore: 16343901

DOI: 10.1016/j.bmcl.2005.11.076