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ID: ALA1138997

Journal: Bioorg Med Chem Lett

Title: Synthesis and antitumor activity of simplified ecteinascidin-saframycin analogs.

Authors: Liu ZZ, Wang Y, Tang YF, Chen SZ, Chen XG, Li HY.

Abstract: Two series of simplified analogs of the ecteinascidin-saframycin type alkaloids were prepared from l-DOPA. Their in vitro antitumor activity was tested against three human cancer cell lines (HCT-8 colon carcinoma, Bel-7402 liver carcinoma, and BGC-823 gastric carcinoma). Among these compounds, the ester analogs have stronger activities than those of amide analogs in general. Among them, 1-naphthalene carboxylate ester analog 31 has the strongest activity against BGC-823 cells.

CiteXplore: 16338237

DOI: 10.1016/j.bmcl.2005.11.069