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ID: ALA1139034
Journal: Bioorg Med Chem Lett
Title: Synthesis and antihyperglycemic evaluation of various protoberberine derivatives.
Authors: Bian X, He L, Yang G.
Abstract: Various berberine derivatives (2-17) were synthesized and their antihyperglycemic activities were evaluated in a model of beta-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure-activity relationships were discussed.
CiteXplore: 16359864