Protein tyrosine phosphatase 1B inhibitors from Morus root bark.
Basic Information
ID: ALA1139039
Journal: Bioorg Med Chem Lett
Title: Protein tyrosine phosphatase 1B inhibitors from Morus root bark.
Authors: Cui L, Na M, Oh H, Bae EY, Jeong DG, Ryu SE, Kim S, Kim BY, Oh WK, Ahn JS.
Abstract: An organic layer prepared from the Chinese crude drug 'Sang-Bai-Pi' (Morus root bark) was studied in order to identify the inhibitory compounds for protein tyrosine phosphatase 1B (PTP1B). Bioassay-guided fractionation resulted in the isolation of sanggenon C (1), sanggenon G (2), mulberrofuran C (3) and kuwanon L (4) as PTP1B inhibitors, along with moracin O (5) and moracin P (6). Compounds 1-4 inhibited PTP1B with IC(50) values ranging from 1.6+/-0.3 microM to 16.9+/-1.1 microM.
CiteXplore: 16356713
DOI: 10.1016/j.bmcl.2005.11.071
Patent ID: ┄