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ID: ALA1139041
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.
Authors: Swahn BM, Xue Y, Arzel E, Kallin E, Magnus A, Plobeck N, Viklund J.
Abstract: The design and synthesis of a new series of c-Jun N-terminal kinase-3 (JNK3) inhibitors with selectivity against JNK1 are reported. The novel series of substituted 2'-anilino-4,4'-bipyridines were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of compounds crystallized into the JNK3 ATP binding active site.
CiteXplore: 16337120