Synthesis and in vitro antitumoral activity of new 3,5-dicyanopyridine derivatives.
Basic Information
ID: ALA1139048
Journal: Bioorg Med Chem
Title: Synthesis and in vitro antitumoral activity of new 3,5-dicyanopyridine derivatives.
Authors: Cocco MT, Congiu C, Lilliu V, Onnis V.
Abstract: A new series of 2-amino-4-aryl-6-dialkylamino-3,5-dicyanopyridines, 20-47, were synthesized in satisfactory overall yield, through a simple synthetic strategy using 3-amino-3-(dialkylamino)-propenenitriles 1 and 2 as key intermediates. 3,5-Dicyanopyridine derivatives 20-47 were evaluated for their in vitro anticancer activity toward cell lines of nine different types of human cancers. Some of the newly prepared compounds demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10(-6) M level and in some cases at 10(-8) M concentration.
CiteXplore: 17142048
DOI: 10.1016/j.bmc.2006.11.031
Patent ID: ┄