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ID: ALA1139093
Journal: Bioorg Med Chem Lett
Title: 1,3-diaminopropan-2-ol sulfonamides as potent and selective inhibitors of the glycine transporter type 1.
Authors: Rahman SS, Coulton S, Herdon HJ, Joiner GF, Jin J, Porter RA.
Abstract: High throughput screening led to the discovery of a novel series of 1,3-diaminopropan-2-ol sulfonamides as selective GlyT-1 inhibitors. Structure-activity relationships of this novel series and optimisation of the initial hit that led to the identification of (2), a potent and selective GlyT-1 inhibitor, are also presented.
CiteXplore: 17234406