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ID: ALA1139167
Journal: Bioorg Med Chem Lett
Title: Synthesis and evaluation of diverse thio avarol derivatives as potential UVB photoprotective candidates.
Authors: Amigó M, Terencio MC, Payá M, Iodice C, De Rosa S.
Abstract: Semisynthesis of 13 new thio avarol derivatives (4-16) and in vitro evaluation on the photodamage response induced by UVB irradiation are described. Their ability to inhibit NF-kappaB activation and TNF-alpha generation in HaCaT cells as well as their antioxidant capacity in human neutrophils has also been studied. Among them we have identified two monophenyl thio avarol derivatives (4-5) lacking cytotoxicity which can be considered promising UVB photoprotective agents through the potent inhibition of NF-kappaB activation with a mild antioxidant pharmacological profile.
CiteXplore: 17317175