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ID: ALA1139191
Journal: Bioorg Med Chem Lett
Title: Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.
Authors: Webster SP, Ward P, Binnie M, Craigie E, McConnell KM, Sooy K, Vinter A, Seckl JR, Walker BR.
Abstract: A series of adamantyl amide 11beta-HSD1 inhibitors has been discovered and chemically modified. Selected compounds are selective for 11beta-HSD1 over 11beta-HSD2 and possess excellent cellular potency in human and murine 11beta-HSD1 assays. Good pharmacodynamic characteristics are observed in ex vivo assays.
CiteXplore: 17350260