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ID: ALA1139268

Journal: Bioorg Med Chem Lett

Title: Camphor sulfonamide derivatives as novel, potent and selective CXCR3 antagonists.

Authors: Wang Y, Busch-Petersen J, Wang F, Kiesow TJ, Graybill TL, Jin J, Yang Z, Foley JJ, Hunsberger GE, Schmidt DB, Sarau HM, Capper-Spudich EA, Wu Z, Fisher LS, McQueney MS, Rivero RA, Widdowson KL.

Abstract: A series of N-arylpiperazine camphor sulfonamides was discovered as novel CXCR3 antagonists. The synthesis, structure-activity relationships, and optimization of the initial hit that resulted in the identification of potent and selective CXCR3 antagonists are described.

CiteXplore: 19014886

DOI: 10.1016/j.bmcl.2008.11.008