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ID: ALA1139327
Journal: Bioorg Med Chem
Title: Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines.
Authors: Canals D, Mormeneo D, Fabriàs G, Llebaria A, Casas J, Delgado A.
Abstract: The synthesis of isomeric jaspines (anhydro phytosphingosines), arising from intramolecular cyclization of the corresponding phytosphingosines with different configurations at C3 and C4 positions of the sphingoid backbone, is reported. Natural jaspine B is the most cytotoxic isomer on A549 cells and it induces cell death in a dose-dependent manner. The cytotoxicity of jaspine B has been correlated with a significant increase of intracellular dihydroceramides, which seem to play an active role in autophagy.
CiteXplore: 19056278