Highly functionalized 7-azaindoles as selective PPAR gamma modulators.

ID: ALA1139415

Journal: Bioorg Med Chem Lett

Title: Highly functionalized 7-azaindoles as selective PPAR gamma modulators.

Authors: Debenham SD, Chan A, Lau FW, Liu W, Wood HB, Lemme K, Colwell L, Habulihaz B, Akiyama TE, Einstein M, Doebber TW, Sharma N, Wang CF, Wu M, Berger JP, Meinke PT.

Abstract: A series of highly functionalized 3-aroyl and 3-phenoxy-2-methyl-7-azaindoles have been identified, which are potent selective PPARgamma modulators (SPPARgammaMs). Addition of substituents at the 6-position of the 7-azaindoles improves in vitro potency and pharmacokinetics. 7-Azaindoles have significantly improved off-target profiles compared to the parent indole series.

CiteXplore: 18701276

DOI: 10.1016/j.bmcl.2008.07.103

Patent ID: ┄