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ID: ALA1139417
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of novel 3'-N-tert-butylsulfonyl analogues of docetaxel.
Authors: Ke B, Qin Y, Zhao F, Qu Y.
Abstract: Novel 3'-N-tert-butylsulfonyl analogues 10a-c of docetaxel were synthesized and their biological evaluation in cytotoxicity in vitro against several human tumor cell lines were presented. The biologically tested results showed that N-oxide pyridyl substituted10b-c had potent cytotoxicities against human tumor cell lines Eca-109, SKOV3, SMMC-7721, HCT-8, PC3, MCF-7, HeLa and KB.
CiteXplore: 18701281