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ID: ALA1139446
Journal: Bioorg Med Chem Lett
Title: 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.
Authors: Ueda S, Terauchi H, Yano A, Ido M, Matsumoto M, Kawasaki M.
Abstract: In our search for a novel class of inducible nitric oxide synthase (iNOS) inhibitors, 1,3-oxazolidin-2-imine was found to weakly inhibit iNOS. Further modifications of this compound resulted in a remarkable increase in both the in vivo and in vitro inhibitory activity and selectivity for iNOS.
CiteXplore: 14698148