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ID: ALA1139448
Journal: Bioorg Med Chem Lett
Title: Synthesis and antibacterial activity of 7-(substituted)aminomethyl quinolones.
Authors: Zhang Z, Zhou W, Yu A.
Abstract: A series of 7-(substituted)aminomethyl quinolones was synthesized and evaluated for antibacterial activity. Derivatives with (monoalkyl)aminomethyl substituent at C-7 displayed high in vitro activities comparable to Lomefloxacin against gram-negative organisms, whereas those bearing a [(substituted)phenyl]aminomethyl side chain at C-7 demonstrated good activities against gram-positive organisms as potent as Lomefloxacin and Vancomycin.
CiteXplore: 14698166