Document Report Card

ID: ALA1139504

Journal: J Med Chem

Title: Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist.

Authors: Ward SE, Harrington FP, Gordon LJ, Hopley SC, Scott CM, Watson JM.

Abstract: A series of 5-(piperidinylethyloxy)quinoline 5-hydroxytryptamine(1D) (5-HT(1D)) receptor antagonists have been discovered from elaboration of the series of dual 5-hydroxytryptamine(1)-selective serotonin reuptake inhibitors (5HT(1)-SSRIs) reported previously. This is the first report of highly potent, selective antagonists for the 5-HT(1D) receptor, which represents an extremely useful set of pharmacological tools for further understanding the roles of the 5-HT(1) receptor subtypes.

CiteXplore: 15887956

DOI: 10.1021/jm049039v