Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties.

ID: ALA1139552

Journal: Bioorg Med Chem Lett

Title: Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties.

Authors: Bruncko M, McClellan WJ, Wendt MD, Sauer DR, Geyer A, Dalton CR, Kaminski MA, Weitzberg M, Gong J, Dellaria JF, Mantei R, Zhao X, Nienaber VL, Stewart K, Klinghofer V, Bouska J, Rockway TW, Giranda VL.

Abstract: A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors.

CiteXplore: 15582418

DOI: 10.1016/j.bmcl.2004.10.026

Patent ID: ┄