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ID: ALA1139553
Journal: Bioorg Med Chem Lett
Title: Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics.
Authors: Ayida BK, Simonsen KB, Vourloumis D, Hermann T.
Abstract: Syntheses of dehydroalanine derivatives via a solid-support route, starting from selenocystein, and via conventional solution phase chemistry are described along with initial biological testing. The target compounds were designed as mimetics of the dehydroalanine side chain of the macrocyclic antibiotic thiostrepton that acts on the bacterial ribosome.
CiteXplore: 15863296