Design, synthesis, and biological evaluation of novel human 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) substrates.

ID: ALA1139590

Journal: Bioorg Med Chem Lett

Title: Design, synthesis, and biological evaluation of novel human 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) substrates.

Authors: Kung PP, Zehnder LR, Meng JJ, Kupchinsky SW, Skalitzky DJ, Johnson MC, Maegley KA, Ekker A, Kuhn LA, Rose PW, Bloom LA.

Abstract: The structure-based design, chemical synthesis, and biological evaluation of novel MTAP substrates are described. These compounds incorporate various C5'-moieties and are shown to have different k(cat)/K(m) values compared with the natural MTAP substrate (MTA).

CiteXplore: 15911263

DOI: 10.1016/j.bmcl.2005.03.107

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