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ID: ALA1139602
Journal: Bioorg Med Chem Lett
Title: Biological evaluation of Tyr6 and Ser7 modified drosocin analogues.
Authors: de Visser PC, van Hooft PA, de Vries AM, de Jong A, van der Marel GA, Overkleeft HS, Noort D.
Abstract: An array of analogues of the cationic antimicrobial peptide drosocin was synthesized containing substitutions of Tyr6 and Ser7 in order to increase the proteolytic stability. Stabilizing the N-terminus with unnatural amino acids increased the serum stability of analogues by almost a factor 30 over an 8 h period.
CiteXplore: 15911277