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ID: ALA1139610
Journal: Bioorg Med Chem Lett
Title: Design, synthesis, and biological evaluation of novel 4-hydro-quinoline-3-carboxamide derivatives as an immunomodulator.
Authors: He JF, Yun LH, Yang RF, Xiao ZY, Cheng JP, Zhou WX, Zhang YX.
Abstract: A series of novel quinoline-3-carboxamide derivatives were synthesized and evaluated for their immunomodulatory activity. The compounds were tested in vitro for effects on spleen lymphocyte proliferation and TNF-alpha production by macrophage. Three compounds showed immunomodulatory profiles similar to and more potent than those of linomide and FR137316 and were selected for further pharmacological studies in vivo.
CiteXplore: 15908212