4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 2. SAR.

ID: ALA1139623

Journal: Bioorg Med Chem Lett

Title: 4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 2. SAR.

Authors: Gunn D, Akuche C, Baryza J, Blue ML, Brennan C, Campbell AM, Choi S, Cook J, Conrad P, Dixon B, Dumas J, Ehrlich P, Gane T, Joe T, Johnson J, Jordan J, Kramss R, Liu P, Levy J, Lowe D, McAlexander I, Natero R, Redman AM, Scott W, Seng T, Sibley R, Wang M, Wang Y, Wood J, Zhang Z.

Abstract: 4,5-Disubstituted cis-pyrrolidinones were investigated as inhibitors of type II 17beta-hydroxysteroid dehydrogenase (17beta-HSD). Early structure-activity relationship patterns for this class of compounds are discussed.

CiteXplore: 15890515

DOI: 10.1016/j.bmcl.2005.04.025

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