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ID: ALA1139630
Journal: Bioorg Med Chem Lett
Title: Structure-activity relationship of N-methyl-bisindolylmaleimide derivatives as cell death inhibitors.
Authors: Katoh M, Dodo K, Fujita M, Sodeoka M.
Abstract: A series of N-methyl-bisindolylmaleimide derivatives was synthesized and evaluated as cell death inhibitors. N-Methyl-2-[1-(3-aminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide (21) was the most potent inhibitor of H2O2-induced necrotic death of human leukemia HL60 cells among them.
CiteXplore: 15896957