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ID: ALA1139638
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents.
Authors: Bhat BA, Dhar KL, Puri SC, Saxena AK, Shanmugavel M, Qazi GN.
Abstract: A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 93 compounds screened, 8 compounds, 1s, 3i,j,n, 4i,j,n and 4s, showed marked activity. Compounds 4j,n and 4s were found to be the most promising in this study. SAR is also discussed.
CiteXplore: 15893928