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ID: ALA1139640
Journal: Bioorg Med Chem Lett
Title: Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia.
Authors: Smith ND, Reger TS, Payne J, Zunic J, Lorrain D, Correa L, Stock N, Cramer M, Chen W, Yang J, Prasit P, Munoz B.
Abstract: A water soluble choline prodrug (17) of a COX-2 selective inhibitor (16) suitable for intravenous dosing in models of cerebral ischemia has been developed. Constant infusion studies using 17 demonstrate that extrapolated brain levels of 16 may be maintained for over 24h in rats.
CiteXplore: 15936193