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ID: ALA1139681
Journal: Bioorg Med Chem Lett
Title: Discovery of orally active butyrolactam 11beta-HSD1 inhibitors.
Authors: Yeh VS, Kurukulasuriya R, Fung S, Monzon K, Chiou W, Wang J, Stolarik D, Imade H, Shapiro R, Knourek-Segel V, Bush E, Wilcox D, Nguyen PT, Brune M, Jacobson P, Link JT.
Abstract: A series of metabolically stable butyrolactam 11beta-HSD1 inhibitors have been synthesized and biologically evaluated. These compounds exhibit excellent HSD1 potency and HSD2 selectivity, pharmacokinetic, and pharmacodynamic profiles.
CiteXplore: 16931002