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ID: ALA1139717
Journal: Bioorg Med Chem Lett
Title: Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors.
Authors: Hwang SH, Morisseau C, Do Z, Hammock BD.
Abstract: A 192-member library of N,N'-disubstituted urea inhibitors was synthesized by a solid-phase method. The ureas were tested for their inhibitory activities against recombinant human soluble epoxide hydrolase. Simple carbocyclic or para/meta-substituted phenyl groups showed inhibition potencies that were equal to or greater than adamantane-based sEH inhibitors, while the presence of bulky or ionizable groups close to the urea group dramatically decreased their activities.
CiteXplore: 16949285