Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans.

ID: ALA1139720

Journal: Bioorg Med Chem Lett

Title: Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans.

Authors: Carrillo R, León LG, Martín T, Martín VS, Padrón JM.

Abstract: In this study, we synthesized a series of enantiomerically pure (2R,3R)-disubstituted tetrahydropyrans with diverse functional groups. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show the relevance for antiproliferative activity of the alpha,beta-unsaturated ester side chain at position 2 of the THP ring.

CiteXplore: 16950618

DOI: 10.1016/j.bmcl.2006.08.094

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