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ID: ALA1139761
Journal: Bioorg Med Chem Lett
Title: Synthesis and optimization of novel and selective muscarinic M(3) receptor antagonists.
Authors: Kumar N, Kaur K, Aeron S, Dharmarajan S, Silamkoti AD, Mehta A, Gupta S, Chugh A, Gupta JB, Salman M, Palle VP, Cliffe IA.
Abstract: A series of constrained piperidine analogues were synthesized as novel muscarinic M(3) receptor antagonists. Evaluation of these compounds in binding assays revealed that they not only have high affinity for the M(3) receptor but also have high selectivity over the M(2) receptor.
CiteXplore: 17629699