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ID: ALA1139785
Journal: Bioorg Med Chem Lett
Title: Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus.
Authors: Raghavan S, Lu Z, Beeson T, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Gabryelski L, Emini E, Tata JR.
Abstract: A series of HIV protease inhibitors with modifications on the P3 position have been designed and synthesized. These compounds exhibit excellent antiviral activity against both the wild type enzyme and PI-resistant clinical viral isolates. The synthesis and biological activity of the compounds are described.
CiteXplore: 17692518