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ID: ALA1139798
Journal: Bioorg Med Chem
Title: Synthesis of chlorogenic acid derivatives with promising antifungal activity.
Authors: Ma CM, Kully M, Khan JK, Hattori M, Daneshtalab M.
Abstract: Derivatives of chlorogenic acid or its analogues were synthesized by coupling protected chlorogenic acid or its analogues with p-octyloxyaniline and selected amino acids. Most of the compounds exhibited significant potency against Cryptococcus neoformans and Candida species with low toxicity to brine shrimps. The 4,5-dihydroxyl groups in the quinic acid moiety were necessary for the activity and introduction of a free amino group increased the inhibitory activity against Aspergillus fumigatus.
CiteXplore: 17761420