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ID: ALA1139808

Journal: Bioorg Med Chem Lett

Title: Structure-activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation.

Authors: Kawai M, Sakurada I, Morita A, Iwamuro Y, Ando K, Omura H, Sakakibara S, Masuda T, Koike H, Honma T, Hattori K, Takashima T, Mizuno K, Mizutani M, Kawamura M.

Abstract: A novel potent NMDA-NR2B selective antagonist without the reactive metabolites formation issue was identified. Through this study, a close correlation between reactive metabolites formation and calculated HOMO energies of parent compounds was found.

CiteXplore: 17766107

DOI: 10.1016/j.bmcl.2007.08.033