Document Report Card
Basic Information
ID: ALA1139827
Journal: Bioorg Med Chem
Title: Synthesis and pharmacological profile of serofendic acids A and B.
Authors: Terauchi T, Asai N, Doko T, Taguchi R, Takenaka O, Sakurai H, Yonaga M, Kimura T, Kajiwara A, Niidome T, Kume T, Akaike A, Sugimoto H.
Abstract: We present efficient syntheses of serofendic acids A and B (SA-A and SA-B), novel neuroprotective substances isolated from fetal calf serum. Biological and pharmacological evaluation showed that SA-A and SA-B have potent protective action against glutamate-induced neurotoxicity, but do not interact directly with glutamate receptors. A pharmacokinetic study showed that they have good oral bioavailability in rats. The results indicate that SA-A and SA-B are potential lead compounds for candidate drugs to treat various neurological disorders.
CiteXplore: 17804246