Document Report Card

ID: ALA1139862

Journal: J Med Chem

Title: Malaria-infected mice are cured by a single dose of novel artemisinin derivatives.

Authors: Posner GH, Paik IH, Chang W, Borstnik K, Sinishtaj S, Rosenthal AS, Shapiro TA.

Abstract: We disclose here for the first time the curative activity of a new generation of trioxane dimers, designed logically and prepared easily from the natural trioxane artemisinin in only four or five chemical steps that would be easily accomplished also on a manufacturing scale. Four of these trioxane dimers cure malaria-infected mice after only a single subcutaneous dose, and two other dimers cure after three oral doses.

CiteXplore: 17439113

DOI: 10.1021/jm070149m