Document Report Card

ID: ALA1139868

Journal: J Med Chem

Title: Synthesis, DNA binding, and Leishmania topoisomerase inhibition activities of a novel series of anthra[1,2-d]imidazole-6,11-dione derivatives.

Authors: Chaudhuri P, Majumder HK, Bhattacharya S.

Abstract: Nine novel anthra[1,2-d]imidazole-6,11-diones, differing in their side chain, were synthesized. UV-vis spectroscopy and viscometric titrations of these molecules with duplex DNA were used to assess their binding with DNA. Five of the nine compounds showed high inhibition activity against topoisomerase I of Leishmania donovani, with the one bearing the tetrazole side chain exhibiting an IC50 approximately 1 microM. The inhibition activities were not related with their DNA binding affinity and depended on the nature of the side chain.

CiteXplore: 17444624

DOI: 10.1021/jm0610604