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ID: ALA1139943
Journal: Bioorg Med Chem Lett
Title: Piperidine amides as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
Authors: Flyrén K, Bergquist LO, Castro VM, Fotsch C, Johansson L, St Jean DJ, Sutin L, Williams M.
Abstract: A series of piperidine amide inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) were identified via modifications of the HTS hit compound 1. The synthesis, in vitro biological evaluation, and structure-activity relationship of these compounds are presented.
CiteXplore: 17442567