Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists.

ID: ALA1139975

Journal: Bioorg Med Chem Lett

Title: Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists.

Authors: Nguyen KT, Claiborne CF, McCauley JA, Libby BE, Claremon DA, Bednar RA, Mosser SD, Gaul SL, Connolly TM, Condra CL, Bednar B, Stump GL, Lynch JJ, Koblan KS, Liverton NJ.

Abstract: A novel series of cyclic benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 29 is orally active in a carrageenan-induced rat hyperalgesia model of pain.

CiteXplore: 17498948

DOI: 10.1016/j.bmcl.2007.04.084

Patent ID: ┄