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ID: ALA1140028
Journal: Bioorg Med Chem Lett
Title: Heterocyclic alpha-helix mimetics for targeting protein-protein interactions.
Authors: Biros SM, Moisan L, Mann E, Carella A, Zhai D, Reed JC, Rebek J.
Abstract: The design and synthesis of alpha-helix peptidomimetics using inverse electron demand Diels-Alder reactions is described. The potency of the resulting pyridazine-based library to disrupt the Bak/Bcl-X(L) interaction was tested using an in vitro fluorescence polarization assay.
CiteXplore: 17555961