Effect of cathepsin K inhibitors on bone resorption.
Basic Information
ID: ALA1140037
Journal: J Med Chem
Title: Effect of cathepsin K inhibitors on bone resorption.
Authors: Teno N, Masuya K, Ehara T, Kosaka T, Miyake T, Irie O, Hitomi Y, Matsuura N, Umemura I, Iwasaki G, Fukaya H, Toriyama K, Uchiyama N, Nonomura K, Sugiyama I, Kometani M.
Abstract: On the basis of the pyrrolopyrimidine core structure that was previously discovered, cathepsin K inhibitors having a spiro amine at the P3 have been explored to enhance the target, bone marrow, tissue distribution. Several spiro structures were identified with improved distribution toward bone marrow. The representative inhibitor 7 of this series revealed in vivo reduction in C-terminal telopeptide of type I collagen in rats and monkeys.
CiteXplore: 18707091
DOI: 10.1021/jm800626a
Patent ID: ┄