Document Report Card

ID: ALA1140059

Journal: J Med Chem

Title: Discovery of potent and selective small-molecule PAR-2 agonists.

Authors: Seitzberg JG, Knapp AE, Lund BW, Mandrup Bertozzi S, Currier EA, Ma JN, Sherbukhin V, Burstein ES, Olsson R.

Abstract: Proteinase activated receptor-2 plays a crucial role in a wide variety of conditions with a strong inflammatory component. We present the discovery and characterization of two structurally different, potent, selective, and metabolically stable small-molecule PAR-2 agonists. These ligands may be useful as pharmacological tools for elucidating the complex physiological role of the PAR-2 receptors as well as for the development of PAR-2 antagonists.

CiteXplore: 18720984

DOI: 10.1021/jm800754r