Document Report Card

ID: ALA1140107

Journal: J Med Chem

Title: Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile.

Authors: Chen J, Collins GT, Zhang J, Yang CY, Levant B, Woods J, Wang S.

Abstract: A series of compounds structurally related to pramipexole were designed, synthesized, and evaluated as ligands for the dopamine 3 (D3) receptor. Compound 12 has a K(i) value of 0.41 nM to D3 and a selectivity of >30000- and 800-fold over the D1-like and D2 receptors, respectively. Our in vivo functional assays showed that this compound is a partial agonist at the D3 receptor with no detectable activity at the D2 receptor.

CiteXplore: 18785726

DOI: 10.1021/jm800471h