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ID: ALA1140196
Journal: Eur J Med Chem
Title: Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins.
Authors: Kalkhambkar RG, Kulkarni GM, Kamanavalli CM, Premkumar N, Asdaq SM, Sun CM.
Abstract: A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, 19F NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein.
CiteXplore: 17959273