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ID: ALA1140237
Journal: Bioorg Med Chem Lett
Title: 6-(2-Phenylethyl)nicotine: a novel nicotinic cholinergic receptor ligand.
Authors: Ramunno A, Dukat M, Lee M, Young R, El-Zahabi M, Damaj MI, Martin B, Glennon RA.
Abstract: 6-(2-Phenylethyl)nicotine (1b; K(i)=15 nM) was unexpectedly found to bind at alpha4beta2 nicotinic cholinergic (nACh) receptors. Although this compound failed to produce nicotine-like agonist action in several functional assays, 1b antagonized the antinociceptive effects of nicotine (mouse tail-flick assay) in a dose-dependent fashion when administered via an intrathecal route.
CiteXplore: 15925512