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ID: ALA1140251
Journal: Bioorg Med Chem Lett
Title: Rhodanine derivatives as inhibitors of JSP-1.
Authors: Cutshall NS, O'Day C, Prezhdo M.
Abstract: Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this class may be useful for the treatment of inflammatory and proliferative disorders.
CiteXplore: 15961311