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ID: ALA1140268
Journal: Bioorg Med Chem Lett
Title: Novel and potent cyclic cyanamide-based cathepsin K inhibitors.
Authors: Deaton DN, Hassell AM, McFadyen RB, Miller AB, Miller LR, Shewchuk LM, Tavares FX, Willard DH, Wright LL.
Abstract: Starting from a PDE IV inhibitor hit derived from high throughput screening of the compound collection, a key pyrrolidine cyanamide pharmacophore was identified. Modifications of the pyrrolidine ring produced enhancements in cathepsin K inhibition. An X-ray co-crystal structure of a cyanamide with cathepsin K confirmed the mode of inhibition.
CiteXplore: 15780613