Document Report Card

ID: ALA1140301

Journal: J Med Chem

Title: Random chemistry as a new tool for the generation of small compound libraries: development of a new acetylcholinesterase inhibitor.

Authors: Kapková P, Heller E, Unger M, Folkers G, Holzgrabe U.

Abstract: Random chemistry, the serendipitous generation of small compound libraries by gamma-irradiation of source compounds, presents a methodology providing reassembled and rearranged structures. The gamma-irradiation was applied to generate new acetylcholinesterase (AChE) inhibitors. The bioassay-guided fractionation as a deconvolution strategy was employed to analyze gained product mixture. The structure of the new highly potent AChE inhibitor, 9-amino-5,6,7,8-tetrahydroacridin-4yl)methanol (1), was elucidated by NMR spectroscopy and ESI (tandem) mass spectrometry.

CiteXplore: 16279811

DOI: 10.1021/jm058041z