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ID: ALA1140419
Journal: Bioorg Med Chem Lett
Title: Synthesis of doxorubicin-peptide conjugate with multidrug resistant tumor cell killing activity.
Authors: Liang JF, Yang VC.
Abstract: Cell penetrating peptide TAT was introduced into doxorubicin structure. Synthesized doxorubicin-TAT conjugate showed different intracellular distribution pattern and cell killing activity from those of free doxorubicin. Unlike free doxorubicin, doxorubicin-TAT conjugate was highly permeable to drug-resistant cells and was able to kill drug-resistant tumor cells efficiently.
CiteXplore: 16168650